CONSTRUCTION OF BHV-1 UL41 DEFECTIVE VIRUS USING THE CRISPR/CAS9 SYSTEM AND ANALYSIS OF VIRAL REPLICATION PROPERTIES

Construction of BHV-1 UL41 Defective Virus Using the CRISPR/Cas9 System and Analysis of Viral Replication Properties

Bovine herpesvirus type 1 Wooden Hanger (BHV-1) is a neurotropic herpesvirus that causes infectious rhinotracheitis and vulvovaginitis in cattle.The virion host shutoff protein encoded by the BHV-1 UL41 gene is highly conserved in the Alphaherpesvirinae subfamily.This protein can degrade viral and host messenger RNA (mRNA) to interrupt host defense

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Exploring the Impact of Data Augmentation Techniques on Automatic Speech Recognition System Development: A Comparative Study

Automatic Speech Recognition (ASR) systems are notorious for their poor performance in adverse conditions, leading to high sensitivity and low robustness.Due to the costly and time-consuming nature of creating extensive speech databases, addressing the issue of low robustness has become a prominent area of research, focusing on Measuring Spoons the

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Integrated metagenomic and metaproteomic analyses reveal bacterial micro-ecological mechanisms in coral bleaching

ABSTRACT Coral bleaching has been rapidly increasing in recent years due to abnormally elevated temperature, leading to massive damage to coral reefs worldwide.Understanding the processes and micro-ecological mechanisms of coral symbionts in response to bleaching is crucial as evidence accumulates that micro-organisms (particularly the bacteria) co

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The impact of COVID-19 on people who inject drugs in New York City: increased risk and decreased access to services

Abstract Background While people who inject drugs (PWID) are vulnerable to the adverse outcomes of events like COVID-19, little is known regarding the impact of the current pandemic on PWID.We examine how COVID-19 has affected PWID in New York City across four domains: substance use, risk behaviors, mental health, and service utilization.Methods As

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